• icon Resource Center
  • icon Kentucky SBIR/STTR
  • icon Federal SBIR/STTR

Welcome to the Kentucky SBIR/STTR Resource Center

The Kentucky SBIR/STTR Resource Center is managed by the Kentucky Science and Engineering Foundation (KSEF), your partner in Kentucky SBIR. 

  • We help Kentucky innovators, entrepreneurs, and technology-oriented small businesses (i.e. 500 or fewer people) who have an innovative concept and need to advance it, translate it into a product or a technology for commercialization, and profit from it.
  • We help prepare you and your Kentucky-based* company for success in the highly competitive Federal Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Programs. These Federal grants allow businesses to conduct feasibility studies in Phase I (up to $150,000) and development of a prototype in Phase II (up to $1,000,000) for eventual commercialization in Phase III using non-federal dollars. Eleven Federal agencies participate in the SBIR Program and five participate in the STTR Program.
  • We offer assistance to qualified Kentucky-based* businesses walking through the SBIR/STTR process including: one-on-one consultation, matching your idea for its best fit with federal agencies, available resources for businesses, training on proposal development, Financial assistance for competitive proposal development, and providing post-award guidance.


  • Take the time to carefully and thoroughly think through your innovative idea.
  • Decide which agencies might have an interest in your unique concept.
  • Visit the websites for those agencies and browse through their solicitations for the topics most closely associated with your innovation. For most people this is not a particularly easy process but don't get discouraged. If you do not get started, you will not reach your destination and get rewarded.




Contact us at  This email address is being protected from spambots. You need JavaScript enabled to view it.  and follow @KSEF_Team on Twitter for the latest news and announcements.

Company Spotlight

  • Natural Products through Genomics

    Naprogenix’s Natural Product Genomics technology platform reverses the order of traditional high-value chemical discovery by first identifying valuable bio-activity, then tracing it to the underlying chemical agents, and finally optimizing the bioactivity in abundant native and crop plant extracts.

    SBIR Funding: Matching Phase I, Matching Phase II

  • Right Time, Right Place, Right People

    3H Company, LLC is a start-up technology company, located in Lexington, KY. 3H Company’s business is in the area of research and development of clean energy technology.

    SBIR Funding: Matching Phase I, Matching Phase II

  • Devices for Cancer Therapy

    Exatherm LLC is dedicated to the development of devices for hyperthermic therapies to treat cancer. The company is planning a clinical trial with lung cancer patients at the University of Kentucky, beginning in January 2012, with a novel whole body circulatory hyperthermia system.

    SBIR Funding: Matching Phase II

  • Devices for Cancer Therapy

    Exatherm LLC is dedicated to the development of devices for hyperthermic therapies to treat cancer. The company is planning a clinical trial with lung cancer patients at the University of Kentucky, beginning in January 2012, with a novel whole body circulatory hyperthermia system.

    SBIR Funding: Matching Phase II

  • Advanced Dynamics is a high-tech firm specializing in 4M modeling and simulation, including aeroelasticity, aeroservoelasticity, aeroservothermoelasticity and propulsion, as well as fluid dynamics, structural mechanics, system dynamics and control, multiphase flows and combustions, etc. As a fast-growing company, Advanced Dynamics is dedicated to the development of 4M Analysis and Optimization software tools for complex mechanical systems, particularly for aerospace vehicles, marine ships and automotives.

    SBIR Funding: Phase Zero, Phase Double Zero, Phase I Matching, Phase II

  • Intranasal Naloxone for Treatment of Suspected Opioid Overdose

    Alcomed is developing a medication, intranasally delivered naloxone, for prevention and treatment of overdose from narcotic medications. The intended populations who could receive the product are patients seen by EMS services, pain management patients, those who have recently undergone deotoxification, or those who are maintained on methadone or buprenorphine.

    SBIR Funding: Matching Phase I

  • A Kentucky Company Providing Health and Medical Products Derived from Blackberries

    Four Tigers LLC was established in 2005 to develop botanical health and medical products derived from blackberries. Four Tigers is developing a pipeline of blackberry-based health products that will be marketed as a cosmetic (vanishing cream), dietary supplement (oral capsule), and food (chewing gum).

    SBIR Funding: Matching Phase I

  • Providing High Quality Contract Services and Products for Antiviral R&D

    IP Pharmaceuticals LLC is dedicated to develop and commercialize novel technologies and reagents for antiviral drug discovery. The company seeks to dis-cover and develop novel therapeutics and vaccines, with a particular emphasis on antiviral drugs to treat infectious diseases caused by viruses such as hepatitis, influenza, West Nile (WNV), Dengue, and respiratory syncytial (RSV) viruses.

    SBIR Funding: Phase Zero, Phase Double Zero

  • New Patented Transformer Design Improves Energy Efficiency and Reduces Cost to Manufacture

    Buswell Energy is an R&D company focused on improvements in transformers and other inductive devices to increase energy efficiency in operation and reduce cost to manufacture. The company has compiled an intellectual property portfolio of eight U.S. patents and will commercialize this technology through licensure to existing manufacturers globally.

    SBIR Funding: Phase Zero, Phase Double Zero

  • 3P Pharmaceuticals seeks to use peptide phage-display to develop biomarkers, research reagents, and therapeutics for multiple diseases and conditions. Our lead therapeutic peptide has been shown to be effective in blocking neuronal cell death and is under investigation in brain injury and related conditions.

    SBIR Funding: Phase Zero, Phase Double Zero

  • Innovative Biological Reagents for the Life Science Research Market

    ECM Biosciences LLC is a life science research company that was founded in 2004 by a team of individuals with over 25 years experience with biological product development, manufacturing, marketing, and distribution. We develop innovative diagnostic tools for research related to cancer, neuropathology, cardiovascular disease, and immune dysfunction.

    SBIR Funding: Phase Double Zero, Matching Phase I, Matching Phase II

  • Development and Commercialization of Innovative Cutting Edge Welding Technologies

    Adaptive Intelligent Systems (AIS) develops and commercializes cutting edge welding technology funded by small business research grants. We offer superior solutions utilizing our unique technologies to our customers to help improve welding productivity and quality.

    SBIR Funding: Phase Zero, Phase Double Zero, Matching Phase I, Matching Phase II

  • Manufacturing a New Type of Paperless Charter Recorders and Hygrometer

    Two Dimensional Instruments LLC develops, manufactures, and markets electronic instruments that monitor and alarm for temperature, humidity, and other variables important to the medical, food manufacturing and industrial markets. Our products are used to insure the health of medicines, vaccines, and temperature sensitive raw materials.

    SBIR Funding: Phase Zero, Phase Double Zero

  • Better Models, Better Results

    Transposagen Biopharmaceuticals Inc. is a privately held biotechnology company that is dedicated to providing unique animal models of human diseases for drug discovery and development. Transposagen is focused on providing unique rat models of human disease and on building a novel rat tissue bank to revolutionize drug discovery research.

    SBIR Funding: Phase Zero, Phase Double Zero, Matching Phase I, Matching Phase II

  • The Smallest Materials for the Biggest Impact

    nGimat LLC specializes in nanomaterials R&D and manufacturing for the energy, electronics, consumer & biomedical industries. nGimat's proprietary NanoSpray Combustion™ Processing technology and Nanomiser™ Device allow low-cost, high-volume production of nanoEngineered Materials™ with unique performance characteristics.

    SBIR Funding: Matching Phase II

  • Developing Technologies Targeting Protein Expression, Natural Insect Control, and Transgenic Technology

    ParaTechs Corp. has multiple proprietary technologies under development that address market-proven needs. Brought to market is a proprietary technology derived from insect viruses that enhances protein expression and reduces input costs in bio-manufacturing.

    SBIR Funding: Phase Double Zero, Matching Phase I, Matching Phase II

  • Natural Product-based Treatments for Oral Diseases

    Oraceuticals Inc. is engaged in the research, development, and commercialization of drugs, nutraceuticals, natural products, and discoveries that advance oral treatment, improve oral health, and enrich lives. The company’s focus is anti-inflammatory, anti-microbial drug development, as well as diagnostics and bioinformatics.

    SBIR Funding: Phase Zero, Phase Double Zero, Matching Phase I, Matching Phase II

  • Recycling High Quality Ceramics from Coal Combustion Ash

    NuForm Materials LLC is company that recycles high quality, value-added ceramics from discarded coal combustion ash. Our process takes raw ash, removes all the contaminants, and classifies it leaving only high quality ceramic particles.

    SBIR Funding: Matching Phase I, Matching Phase II

  • Putting Life to the Test

    ALT BioScience LLC is a privately held diagnostics company located in Lexington, KY. ALT’s test strip technology consists of point-of-care diagnostic applications in the detection and monitoring of oral health conditions for professionals and consumers.

    SBIR Funding: Phase Zero, Phase Double Zero

  • Stallion Therapeutics Inc. is a Lexington based start-up pharmaceutical company developing neuroprotective and neurorestorative compounds for traumatic brain injury, spinal cord injury and other acute neurological disorders.

    SBIR Funding: Matching Phase I

  • Targeting Alzheimer’s Disease

    Scout Diagnostics is developing a immunoassay to detect Alzheimer’s disease.

    A patent covering the test was issued on December 13, 2010. In September 2010, the company received a grant from NIH for $951,000.

    SBIR Funding: Matching Phase I, Matching Phase II

  • Rehabilitation Products for Individuals with Spinal Cord Injury, Stroke, Sports Medicine

    customKYnetics Inc. is an early-stage research and development company that focuses on development of rehabilitation engineering products. The primary focus is to design and develop systems that use electrical stimulation in modalities that have the potential to build muscle mass, strength, and endurance or to promote motor retraining.

    SBIR Funding: Matching Phase I, Matching Phase II

  • Direct i2i is a start-up company focusing on high definition video and audio collaboration solutions. Based on over eight years of research by Dr. Ruigang Yang, the company was founded in 2006 with the goal of creating the next generation of teleconferencing systems to allow geographically distributed people to meet and collaborate as if they were in the same room.  Initial Funding was provided by the small business technology transfer (STTR) program of the US National Science Foundation and Kentucky Science and Technology Cooperation.

    SBIR Funding: Phase Double Zero, Phase I Matching

  • Proprietary Natural Products for the Flavor and Fragrance and Insect Repellent Markets

    Allylix is focused on the production of natural products called terpenes for the flavor and fragrance and insect repellent markets. Allylix's proprietary technology platform uses the most advanced tools in molecular genetics, biochemistry and structural biology, and fermentation to produce valuable natural products cost effectively.

    SBIR Funding: Phase Zero, Phase Double Zero, Phase I Matching

  • Developing in situ Nanoparticle Additives for Multifunctional Nanocoatings

    Topasol is a pioneering UK start-up company that develops and manufactures additives for multifunctional nanocoatings and was founded in Lexington, Kentucky.

    SBIR Funding: Matching Phase I, Matching Phase II

  • Innovative Medication Dispenser Solutions to Address Patient Compliance

    Dose Control LLC was founded to research, develop, manufacture, and market innovative dispenser solutions to deter prescription drug abuse and increase medication adherence. Our patented device is a programmable, tamper-resistant, portable, refillable dispenser, designed to dispense pills to the patient no faster than the prescribed and programmed rate.

    SBIR Funding: Phase Zero, Phase Double Zero

  • Providing Inovative Solutions for Energy and Environmental Issues

    Neathery Technologies Inc. specializes in providing process/product research and development and consulting to firms requiring energy con-version, pollution prevention, process engineering and environmental control expertise.

    SBIR Funding: Matching Phase I

  • Developing Biological Control Methods for Mosquito Control

    SBIR Funding: Phase Zero

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Contact Us: sbir@kstc.com

Kentucky Science & Technology Corporation
200 West Vine Street, Suite 420,
Lexington, KY 40507

 Our Team: Contact Us

Conferences, Workshops, and SBIR Connect

"SBIR Connect-Lexington" meets the second Tuesday of each month and "SBIR Connect-Louisville" meets the second Thursday of each month. These SBIR/STTR networking events are free; no registration is required. Just walk in and connect with others to learn some inside tips on winning SBIR/STTR grants. Contact Mahendra Jain PhD 859.246.3230 for time and location details.

The Kentucky Science & Engineering Foundation (KSEF) and partner organizations sponsor events to help you through the SBIR/STTR programs. Read More about our Phase I and Phase II SBIR/STTR proposal development workshops, and Kentucky SBIR/STTR Annual Conference.

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